| 摘要 |
PROBLEM TO BE SOLVED: To obtain an amine widely usable as e.g. a raw material for medicines, solvent, catalyst, ligand, under mild conditions in high yield and selectivity, by hydrogenating reduction of an amide in a hydrocarbon solvent in the presence of a specific catalyst. SOLUTION: This amine is obtained by hydrogenating reduction of an amide in the presence of a catalyst composed of at least one element selected from among group VIII elements (pref. rhodium, ruthenium, palladium) and at least one element selected from among group VIb elements (pref. molybdenum, tungsten) or group VIIb elements (pref. rhenium) [pref. Ru/Al2 O3 -Mo(CO)6 , Rh/Al2 O3 - Re2 (CO)10 ]. Using the above reaction, for example, (S)-N-(1-phenylethyl)acetamide is converted into (S)-N-(1-cyclohexylethyl)ethylamine. |
