发明名称 |
Diagnostics and treatments for cancers expressing tyrosine phosphorylated CRKL protein |
摘要 |
The invention relates to methods and kits for diagnosing cancers arising from cells which express tyrosine phosphorylated CRKL protein, such as cells having the Philadelphia (Ph) chromosome, which includes chronic myelogenous leukemia (CML) and acute lymphoblastic leukemia (ALL), through the detection of increased levels of phosphorylated CRKL protein or through the detection of increased CRKL gene copy or mRNA expression. The invention also relates to methods of treating such cancers.
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申请公布号 |
US5667981(A) |
申请公布日期 |
1997.09.16 |
申请号 |
US19940242513 |
申请日期 |
1994.05.13 |
申请人 |
CHILDRENS HOSPITAL OF LOS ANGELES |
发明人 |
GROFFEN, JOHN H.;HEISTERKAMP, NORA C.;HOEVE, JOHANNA TEN |
分类号 |
A01K67/027;A61K9/127;A61K31/70;A61K38/00;A61K38/55;A61K48/00;A61P35/00;C07K14/82;C12N15/09;C12N15/12;C12P21/08;G01N33/53;G01N33/574;G01N33/68;(IPC1-7):G01N33/574 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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