摘要 |
Process for the preparation of N-methyl-3-phenyl-3-(p- trifluoromethylphenoxy) propylamine Comprises the following stages: causing benzyl alcohol to react first with sodium hydride in dimethylacetamide and then with 1-chloro-4-(trifluoromethyl)benzene in order to obtain benzyl p-trifluoromethylphenyl ether, converting this into 4-phenyl-4-(p-trifluoromethylphenoxy)butene by reaction with first n-butyl-lithium/tetramethylethylene diamine reagent and then with allyl bromide, converting the product obtained into 3-phenyl-3-(p- trifluoromethylphenoxy)propanol using an ozonolysis reaction, converting the product obtained into title product I by reaction with methylamine under the conditions of formation of the corresponding imine, and subsequent in situ reduction of the imine formed using sodium cyanoborohydride. Finally product I is converted into its hydrochloride by adding hydrogen chloride. The invention is of use in the advantageous industrial preparation of I.
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