| 摘要 |
The invention concerns a process for preparing 1,4-disubstituted piperidine compounds of formula (I), in which Y = -(CH2)n, n being 0, 1, 2 or 3; oxygen; sulphur; vinyl; -CH2-O-; -O-CH2; -CH2-S- or -S-CH2; and R and Z mean substituents known per se. Compounds in which Z means -CH2-CH2- are produced in that the correspondingly substituted 5,6-dihydro-11H-benzo[5,6]-cyclohepta-[1,2-b]pyridin-11-one compound is reacted with the corresponding 1-substituted 4-piperidone in a single process step by means of reductive dimerization in the presence of a finely dispersed metal of the IVth and/or Vth and/or VIth subgroup of the periodic table of elements or a low-valent oxidation stage of a corresponding metal compound of this type, the finely dispersed metal or the low-valent oxidation stage being produced in situ by means of a reducing agent and in the presence of an inert solvent. Preferably 4-(5,6-dihydro-11H-benzo-[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-1-p iperidine compounds are produced.
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