| 摘要 |
<p>Fused heterocyclic compounds represented by general formula (I), wherein each symbol is as defined in the description, optical isomers thereof, or pharmaceutically acceptable salts thereof; pharmaceutical compositions containing the compounds of formula (I), the optical isomers or pharmaceutically acceptable salts thereof, and pharmaceutically acceptable additives; and medicines containing the compounds of formula (I), the optical isomers thereof, or the pharmaceutically acceptable salts thereof. These compounds are useful antipsychotic agents efficacious against not only positive symptoms centering on the hallucination, delusion and the like peculiar to the acute stage of schizophrenia, but also negative symptoms such as emotional torpidity, abulia and autism. They are also expected as highly safe antipsychotic agents reduced in the side effects, such as extrapyramidal symptoms or abnormal internal secretion, observed in the case of administration of conventional antipsychotic agents having D2 receptor blocking effects. Thus these compounds can be used as remedies for diseases including schizophrenia.</p> |
