发明名称 |
GENETICALLY ENGINEERED PRIMARY OLIGODENDROCYTES FOR TRANSPLANTATION-MEDIATED GENE DELIVERY IN THE CENTRAL NERVOUS SYSTEM |
摘要 |
The present invention pertains to a method for transplanting genetically engineered primary cells into the central nervous system of a patient. The method comprises the steps of (a) isolating primary oligodendrocyte progenitor cells from the brain of a patient; (b) expanding the cells in vitro with mitogens; (c) genetically engineering the cells by introducing transgenes through an eukaryotic expression vector for DNA-mediated gene transfer into the cells; and (d) transplanting the genetically engineered primary cells into the brain of the patient.
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申请公布号 |
CA2247912(A1) |
申请公布日期 |
1997.09.12 |
申请号 |
CA19972247912 |
申请日期 |
1997.02.28 |
申请人 |
UNIVERSITY OF MEDICINE & DENTISTRY OF NEW JERSEY |
发明人 |
MCKINNON, RANDALL D. |
分类号 |
A61K35/12;A61K48/00;C12N5/079;C12N15/867;(IPC1-7):C12N5/10;A61K35/30 |
主分类号 |
A61K35/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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