O-alkylated rapamycin derivatives and their use, particularly as immunosuppressants

摘要

PCT No. PCT/EP93/02604 Sec. 371 Date Apr. 7, 1995 Sec. 102(e) Date Apr. 7, 1995 PCT Filed Sep. 24, 1993 PCT Pub. No. WO94/09010 PCT Pub. Date Apr. 28, 1994Novel derivatives of rapamycin, particularly 9-deoxorapamycins, 26-dihydro-rapamycins, and 40-0-substituted and 28,40-0,0-di-substituted rapamycins, are found to have pharmaceutical utility, particularly as an immunosuppressants.