Process for preparing 1,5-benzothiazepine derivative

摘要

A novel process for preparing 1,5-benzothiazepine derivative ÄIIÜ: <CHEM> wherein Ring A and Ring B are substituted or unsubstituted benzene ring, and R<3> is H, (di-lower alkylamino)-lower alkyl or substituted or unsubstituted piperazinyl-lower alkyl, or a salt thereof, in high yield and in a single step from a novel 3-(2-amino-substituted or unsubstituted phenylthio)-2-hydroxy-3-substituted or unsubstituted phenylpropionamide compound. Said 1,5-benzothiazepine derivative ÄIIÜ is useful as an intermediate for preparing medicaments such as diltiazem hydrochloride.