| 摘要 |
An isolated and purified nucleic acid comprising a nucleotide sequence which consists of GAT CCA CTG TGC GAC AGC TCG GRG ATC (Seq. Id. No. 1) included in the proto-oncogene RET, which sequence in normal cells has the following sequence in the region defined by position 1810 and adjacent nucleotides including position 1845 and adjacent nucleotides: GAT CCA CTG TGC GAC GAG CTG TGC CGC ACG GTG ATC. Information derived from the altered nucleotide sequence found in a tissue or fluid sample, taken from a patient, can be used for determining the type and character of the rumor. The nucleotide sequence or information derived therefrom is used for the manufacture of reagents for the diagnosing of cancer and for the manufacture of pharmaceutical compositions for prevention and/or treatment of cancer. |
