| 摘要 |
The invention relates to crystallized apopain, the use of that structure to solve the structure of apopain homologues and other crystal forms of apopain, mutants and co-complexes of apopain, and the use of the apopain structure and that of its homologues, mutants, and co-complexes to design modulators of apopain.
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| 申请人 |
MERCK & CO., INC.;MERCK FROSST CANADA INC.;NICHOLSON, DONALD, W.;FAZIL, KIMBERLY, A.;GALLANT, MICHEL;GAREAU, YVES;LABELLE, MARC;RASPER, DITA, M.;RUEL, REJEAN;VAILLANCOURT, JOHN, P.;BECKER, JOSEPH, W.;ROTONDA, JENNIFER;THORNBERRY, NANCY, A.;PETERSON, ERIN, P. |
发明人 |
NICHOLSON, DONALD, W.;FAZIL, KIMBERLY, A.;GALLANT, MICHEL;GAREAU, YVES;LABELLE, MARC;RASPER, DITA, M.;RUEL, REJEAN;VAILLANCOURT, JOHN, P.;BECKER, JOSEPH, W.;ROTONDA, JENNIFER;THORNBERRY, NANCY, A.;PETERSON, ERIN, P. |
