发明名称 |
INHIBITORS OF FARNESYL PROTEIN TRANSFERASE |
摘要 |
This invention relates to compounds that inhibit farnesyl-protein transferase and ras protein farnesylation, thereby making them useful as anti-cancer agents. The compounds are also useful in the treatment of diseases, other than cancer, associated with signal transduction pathways operating through ras and those associated with proteins other than ras that are also posttranslationally modified by the enzyme farnesyl protein transferase. The compounds may also act as inhibitors of other prenyl transferases, and thus be effective in the treatment of diseases associated with other prenyl modifications of proteins.
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申请公布号 |
CA2239187(A1) |
申请公布日期 |
1997.08.28 |
申请号 |
CA19972239187 |
申请日期 |
1997.02.24 |
申请人 |
BRISTOL-MYERS SQUIBB COMPANY |
发明人 |
MITT, TOOMAS;HUNT, JOHN T.;DING, CHARLES Z.;BHIDE, RAJEEV;LEFTHERIS, KATERINA;KIM, SOONG-HOON |
分类号 |
C07D401/14;A61K31/00;A61K31/35;A61K31/4178;A61K31/495;A61K31/498;A61K31/55;A61K31/551;A61K31/5513;A61K31/675;A61P35/00;A61P43/00;C07D;C07D243/14;C07D245/06;C07D401/04;C07D401/10;C07D403/06;C07D403/12;C07D403/14;C07D405/14;C07D407/14;C07D409/14;C07D413/06;C07D413/12;C07D413/14;C07D417/04;C07D417/14;C07D453/02;C07D471/04;C07D473/00;C07D487/04;C07D491/044;C07D491/048;C07D495/04;C07D497/04;C07D513/04;C07F9/645;(IPC1-7):C07D403/06 |
主分类号 |
C07D401/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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