PROCESS FOR DETERMINING THE PHOTOTOXICITY AND/OR PHOTOSENSITIVITY OF SUBSTANCES OR MIXTURES THEREOF, AND USE THEREOF

摘要

The invention relates to a process for determining the phototoxicity and/or photosensitivity of substances or mixtures thereof, including bringing the chemical substance or substance mixture into contact with a non-human vertebrate embryo or tissues or tissue components of a vertebrate embryo, with the exception of human skin cell cultures. After contacting, there is also treatment with electromagnetic radiation in the range of 1 mm to 200 nm, and subsequent evaluation of the embryo pathology, tissue pathology or cell pathology. The invention also relates to the use of a non-human vertebrate embryo or tissues or tissue components of such a vertebrate embryo, with the exception of human skin cell cultures, to determine the phototoxicity and/ or photosensitivity of chemical substances or mixtures thereof.