发明名称 |
DIAGNOSTIC METHOD AND KIT FOR DETERMINING KELL BLOOD GROUP GENOTYPE |
摘要 |
The invention provides a diagnostic method of determining Kell genotype by the identification of the molecular basis of a Kell polymorphism. Specifically, the invention provides a method for determining K6/K7 genotype with great accuracy, overcoming problems associated with traditional serological typing methods. The diagnostic method of the invention preferably employs amplification of K6/K7 nucleic acid sequences, and optionally employs differential cleavage of K6-K7 specific nucleic acid sequences by a restriction enzyme. Also provided are nucleic acid oligomers useful as probes or primers for the method of the invention. Furthermore, diagnostic kits for the determination of Kell genotype are provided. |
申请公布号 |
EP0791076(A1) |
申请公布日期 |
1997.08.27 |
申请号 |
EP19950940686 |
申请日期 |
1995.11.09 |
申请人 |
THE NEW YORK BLOOD CENTER, INC. |
发明人 |
LEE, SOOHEE;REDMAN, COLVIN, L. |
分类号 |
C12N15/09;C07K14/705;C12N5/10;C12P21/00;C12Q1/68 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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