| 发明名称 |
Process for antibody directed enzyme prodrug therapy |
| 摘要 |
Prodrugs, of generic formula I, are disclosed for use in antibody directed enzyme prodrug therapy (ADEPT). The prodrugs are substrates for carboxypeptidase G2 (CPG2) and yield more active cytotoxic drugs than known products of CPG2 catalysed reactions.
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| 申请公布号 |
US5660829(A) |
申请公布日期 |
1997.08.26 |
| 申请号 |
US19950442348 |
申请日期 |
1995.05.16 |
| 申请人 |
ZENECA LIMITED;CANCER RESEARCH CAMPAIGN TECHNOLOGY |
发明人 |
BURKE, PHILIP JOHN;DOWELL, ROBERT IAN;MAUGER, ANTHONY BRIAN |
| 分类号 |
A61K31/17;A61K31/195;A61K31/27;A61K31/41;A61K39/395;A61K45/00;A61K47/48;A61P35/00;A61P43/00;C07C237/20;C07C237/40;C07C269/04;C07C271/54;C07C275/24;C07C275/40;C07C275/42;C07C309/66;C07C309/69;C07C309/72;C07C311/51;C07C317/50;C07C323/58;C07D257/04;(IPC1-7):A61K39/395;C07K16/00;C07C261/00;C07F9/02 |
主分类号 |
A61K31/17 |
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