A polypeptide from lung extract which binds amyloid-beta peptide

摘要

The present invention provides for a method for inhibiting interaction of an amyloid- beta peptide with a receptor for advanced glycation end product on the surface of a cell which comprises contacting the cell with an agent capable of inhibiting interaction of the amyloid- beta peptide with the receptor for advanced glycation end product, the agent being present in an amount effective to inhibit interaction of the amyloid- beta peptide with the receptor for advanced glycation end product on the surface of the cell. Another embodiment of this invention is a method for evaluating the ability of an agent to inhibit binding of an amyloid- beta peptide with a receptor for advanced glycation end product on the surface of a cell which includes: a) contacting the cell with the agent and amyloid- beta peptide; b) determining the amount of amyloid- beta peptide bound to the cell and c) comparing the amount of bound amyloid- beta peptide determined in step b) with the amount determined in the absence of the agent, thus evaluating the ability of the agent to inhibit the binding of amyloid- beta peptide to the receptor for advanced glycation end product on the surface of the cell.