| 摘要 |
The invention relates to an artificial bone mineral for use in medicine and to a process for preparing the same. The bone mineral has a crystal structure and mineral microstructure substantially the same as natural bone and thus permits physiologically controlled, cell mediated remodelling on implantation. The bone mineral, however, has an organic impurity content below 150 parts per million. The bone mineral is produced by degrading and solubilizing degreased bone by heating with ammonia or a primary amine, and extracting the solubilized degradation products by washing with flowing water at temperatures below 60.degree.C. If necessary the degrading and washing steps may be repeated to remove substantially all of the organic matter. The bone mineral, treated in this way, is then heated in air at temperatures between 250.degree.C-600.degree.C.
|
