发明名称 |
Inducible nitric oxide synthase gene for treatment of disease |
摘要 |
The present invention discloses a full-length human hepatocyte iNOS cDNA clone and various gene therapy applications utilizing an iNOS DNA sequence. In preferred embodiments of the disclosed invention, iNOS-directed gene therapy involves specific targeting of a DNA sequence encoding a protein or protein fragment with iNOS biological activity for treating vascular diseases and disorders, antitumor applications and in response to certain microbial infections.
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申请公布号 |
US5658565(A) |
申请公布日期 |
1997.08.19 |
申请号 |
US19940265046 |
申请日期 |
1994.06.24 |
申请人 |
UNIVERSITY OF PITTSBURGH OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION |
发明人 |
BILLIAR, TIMOTHY R.;TZENG, EDITH;NUESSLER, ANDREAS K.;GELLER, DAVID A.;SIMMONS, RICHARD L. |
分类号 |
C12N15/09;A61K35/76;A61K38/00;A61K48/00;A61P9/14;C07H21/04;C12N5/10;C12N9/02;C12N9/06;C12N15/86;(IPC1-7):A61K48/00 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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