发明名称 |
Pharmaceutical solution which releases nitric oxide without oxygen@ - on increase in temperature, consists of sodium chloride solution saturated with nitric oxide |
摘要 |
Pharmaceutical preparation consists of a sterile, injectable, physiologically acceptable solution which releases nitric oxide, NO, free from oxygen, on increase in temperature. The solution comprises a 0.9% sodium chloride solution which is saturated with NO. Also claimed is a process for quantitative determination of endothelial dysfunction in mammals. The process comprises (a) transferring a measured volume of whole blood into an equal volume of 1M NaOH as a stop solution, under conditions which exclude oxygen; (b) adding 50 mu l 1M phosphoric acid and centrifuging the mixture for 5 minutes at 10000g; (c) decanting the supernatant into an ultrafiltration tube and centrifuging for 15 minutes at 2000g; (d) diluting the ultrafiltrate with HPLC-water (1:10); and determining the nitrite content by known methods. -
|
申请公布号 |
DE19604361(A1) |
申请公布日期 |
1997.08.14 |
申请号 |
DE19961004361 |
申请日期 |
1996.02.07 |
申请人 |
SCHWARZ PHARMA AG, 40789 MONHEIM, DE |
发明人 |
KELM, MALTE, 40225 DUESSELDORF, DE |
分类号 |
A61K33/00;A61K33/14;G01N33/84;(IPC1-7):A61K33/00;A61K31/21 |
主分类号 |
A61K33/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|