| 摘要 |
Compounds having structure (I), where m is an integer of from one to nine; n is an integer of from one to four; W is selected from unsubstituted quinolyl, benzothiazolyl, or quinoxalyl, or quinolyl, benzothiazolyl, or quinoxalyl substituted with one, two or three substituents selected from the group consisting of halogen, C1-6 alkyl, and C1-6 alkoxy; X is absent or is selected from the group consisting of (a) C1-6 alkylene; (b) C1-6 alkenylene; and (c) C1-6 alkynylene; Y is one to four substituents independently selected from halogen, C1-6 alkyl, and C1-6 alkoxy; Z is selected from the group consisting of (a) COB; (b) C(R<2>)2-O-N=A-COB; and (c) C(R<2>)=N-O-A-COB where A is C1-6 alkylene, and B is selected from the group consisting of (a) -OH; (b) -O<->M<+> where M is a pharmaceutically acceptable cation; (c) -OR<6> where R<6> is hydrogen or alkyl of one to six carbon atoms; (d) -NR<6>R<7> where R<6> is as previously defined and R<7> is selected from the group consisting of hydrogen, alkyl of one to six carbon atoms, hydroxy, and alkoxy of from one to six carbon atoms, or R<6> and R<7>, together with the atom to which they are attached, form a ring of five to eight members containing one optional heteratom selected from N, O and S; and (e) -O-D where D is a metabolically cleavable group, are inhibitors of leukotriene biosynthesis.
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