发明名称 |
ANTIBODIES AND IMMUNOGLOBULIN FUSION PROTEINS HAVING MODIFIED EFFECTOR FUNCTIONS AND USES THEREFOR |
摘要 |
CTLA4-immunoglobulin fusion proteins having modified immunoglobulin constant region-mediated effector functions, and nucleic acids encoding the fusion proteins, are described. The CTLA4-immunoglobulin fusion proteins comprise two components: a first peptide having a CTLA4 activity and a second peptide comprising an immunoglobulin constant region which is modified to reduce at least one constant region-mediated biological effector function relative to a CTLA4-IgG1 fusion protein. The nucleic acids of the invention can be integrated into various expression vectors, which in turn can direct the synthesis of the corresponding proteins in a variety of hosts, particularly eukaryotic cells. The CTLA4-immunoglobulin fusion proteins described herein can be administered to a subject to inhibit an interaction between a CTLA4 ligand (e.g., B7-1 and/or B7-2) on an antigen presenting cell and a receptor for the CTLA4 ligand (e.g., CD28 and/or CTLA4) on the surface of T cellsto thereby suppress an immune response in the subject, for example to inhibit transplantation rejection, graft versus host disease or autoimmune responses.
|
申请公布号 |
CA2243986(A1) |
申请公布日期 |
1997.08.07 |
申请号 |
CA19972243986 |
申请日期 |
1997.02.03 |
申请人 |
REPLIGEN CORPORATION |
发明人 |
JELLIS, CINDY L.;CARSON, JERRY;RENNERT, PAUL D.;GRAY, GARY S.;SILVER, SANDRA;JAVAHERIAN, KASHI |
分类号 |
A61K38/00;C07K14/705;C12N1/21;(IPC1-7):C12N15/62;C07K16/00;C07K19/00;C12N15/12;C12N15/13;A61K38/17;A61K47/48;G01N33/53 |
主分类号 |
A61K38/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|