发明名称 |
Borna disease virus-specific protein and kits |
摘要 |
Borna disease virus (BDV) causes a rare neurological disease in horses and sheep. A subtractive cDNA expression library was constructed with poly A-selected RNA from a BDV infected MDCK cell line. A clone (B8) was isolated that specifically hybridizes to RNA isolated from BDV-infected brain tissue and BDV-infected cell lines. This clone hybridizes to four BDV-specific positive strand RNAs and one negative strand RNA in BDV-infected rat brain. Nucleotide sequence analysis of the clone suggests that it represents a full length mRNA which contains several open reading frames. The Borna Disease Virus DNA sequences as well as proteins encoded by the BDV DNA sequences are provided.
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申请公布号 |
US5654401(A) |
申请公布日期 |
1997.08.05 |
申请号 |
US19940351176 |
申请日期 |
1994.11.30 |
申请人 |
THE JOHNS HOPKINS UNIVERSITY |
发明人 |
CLEMENTS, JANICE E.;NARAYAN, OPENDRA;VANDEWOUDE, SUSAN;RICHT, JUERGEN A. |
分类号 |
C07K14/08;C12N15/31;(IPC1-7):C07K1/00;C07K14/00;C12P21/06;C12Q1/70 |
主分类号 |
C07K14/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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