| 摘要 |
<p>This invention pertains to nucleoside analogs which have antiviral activity and improved metabolic stability, compositions comprising them, and methods of antiviral treatment employing them. More particularly, this invention pertains to imidazo [1,2-a]pyridine C-nucleosides, as exemplified by compounds such imidazo[1,2-a]pyridine C5-nucleosides and imidazo[1,2-a]pyridine C3-nucleosides, and may be represented by formula (I), wherein exactly one of Q?3 and Q5¿ is a sugar-like moiety; exactly one of Q?3 and Q5¿ is -H; and Q?2, Q6, Q7 and Q8¿ are independently imidazo[1,2-a]pyridine substituents, such as -H, -F, -Cl, -Br, and -I.</p> |
