NUCLEIC ACIDS AND PROTEINS RELATED TO ALZHEIMER'S DISEASE, AND USES THEREFOR

摘要

The present invention describes the identification, isolation, sequencing and characterization of several human genes which interact with the presenilins, mutations in which may lead to Familial Alzheimer's Disease. These presenilininteracting protein genes may be involved in the pathways which, when affected by mutant presenilins, lead to the development of Alzheimer's Disease. In addition, mutations in the presenilin-interacting protein genes, even in the absence of defects in the presenilins, may be causative of Alzheimer's Disease. Nucleic acids and proteins comprising or derived from the presenilininteracting proteins are useful in screening and diagnosing Alzheimer's Disease, in identifying and developing therapeutics for treatment of Alzheimer's Disease, and in producing cell lines and transgenic animals useful as models of Alzheimer's Disease.