Organosilane derivatives, pharmaceutical compositions containing them and process for preparing same

摘要

The invention relates to novel organosilanes of the formula (I) wherein m is 1, 2 or 3; R<1> and/or R<2> represents hydrogen, a straight or branched C1-4alkyl, C1-4alkoxy, C5-7cycloalkyl group or halogen; B represents a 5- or 6-membered saturated or unsaturated heterocyclic group which contains one or more nitrogen atoms and optionally an additional oxygen or sulfur atom or -NH or -NR group, wherein R represents a C1-5alkyl or (C1-5 alkyl)carbonyl group, said heterocyclic group being bound through a nitrogen atom to the (CH2)m group and optionally substituted by a C1-4alkyl or (C1-4alkoxy)carbonyl group; and acid addition salts thereof. The compounds of the formula (I) show a strong muscle relaxant effect and antiparkinsonic properties; thus, they are useful for the treatment of Parkinson's disease, spastic, rigid muscular hypertonicity, stroke, nervous system laesions, sclerosis multiplex, myelopathies, rachicele or particular pains. A process for the preparation of compound of formula (I) and pharmaceutical compositions containing them are also described.