| 摘要 |
PROBLEM TO BE SOLVED: To improve living body affinity, cell intrusion performance, biodegradation, anastaltic performance, transparency, and sustained release performance of drug by treating atherocollagen solution by metal ion and cross- link accelerating agent so as to prepare collagen gel which absorbs moisture of specific times of dry weight. SOLUTION: Water insoluble collagen get which is used as a filling material, ointment, a base material for poultice, a wound covering material, etc., for the living tissue such as the skin and the bone is provided by treating atherocollagen solution by metal ion of 0.1mM or more and cross-link accelerating agent so as to absorb water of 20-200 times the dry weight. Ascorbic acid, tocopherol group, or hydrogen peroxide is used for this cross-link accelerating agent. Such collagen is dried so that a collagen sheet is provided and the collagen gel is preferable to be manufactured by adding chelating agent, after the metal ion of 0.1mM or more and the cross-link accelerating agent are added to the atherocollagen solution so as to act thereon. |
