| 发明名称 |
DETECTION OF A LEPTIN RECEPTOR VARIANT AND METHODS FOR REGULATING OBESITY |
| 摘要 |
The present invention relates to a variant form of the receptor for the obese gene product. In particular, the invention relates to methods of detecting this receptor variant in cells and tissues of obese individuals. In addition, it relates to methods of inhibiting or down-regulating expression of this variant in cells to augment their responsiveness to weight regulation by leptin as well as methods of using compounds to directly activate signal transduction pathways associated with this ligand-receptor system. |
| 申请公布号 |
WO9726523(A2) |
申请公布日期 |
1997.07.24 |
| 申请号 |
WO1997US00881 |
申请日期 |
1997.01.17 |
| 申请人 |
PROGENITOR, INC. |
发明人 |
SNODGRASS, H., RALPH;CIOFFI, JOSEPH;ZUPANCIC, THOMAS, J.;SHAFER, ALAN, W. |
| 分类号 |
G01N33/53;A61K31/7088;A61K38/00;A61K45/00;A61K48/00;A61P7/00;A61P7/06;A61P35/00;C07K14/705;C07K14/715;C07K14/72;C07K16/24;C07K16/28;C07K19/00;C12N1/21;C12N5/10;C12N15/00;C12N15/02;C12N15/09;C12P21/02;C12P21/08;C12Q1/68;C12R1/91;G01N33/50;G01N33/566 |
主分类号 |
G01N33/53 |
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