发明名称 |
Reactant for attaching substd di:fluoromethyl gp. to electrophilic cpd. |
摘要 |
<p>Nucleophilic reactant used for grafting a substd. difluoromethyl gp. onto an electrophilic cpd., comprises: (a) a fluorocarboxylic acid of formula Ea-CF2-COOH where Ea is electron-attracting atom or gp. at least partially salted by organic or mineral cation; and (b) a polar aprotic solvent. The content of potentially-free portions present in different components (i.e. impurities) is at most, equal to half initial molar concn. of the fluorocarboxylic acid. Also claimed is the method of synthesis of a deriv. incorporating the difluoromethylene gp. comprising: (i) reacting an electrophilic cpd. with the above reagent; and (ii) heating the mixt. at 100-200 deg.C for 1/2 hr. to one day.</p> |
申请公布号 |
FR2743065(A1) |
申请公布日期 |
1997.07.04 |
申请号 |
FR19950015763 |
申请日期 |
1995.12.29 |
申请人 |
RHONE POULENC CHIMIE |
发明人 |
FORAT GERARD;MAS JEAN-MANUEL;SAINT-JALMES LAURENT |
分类号 |
C07C29/38;C07C29/62;C07C45/48;C07C45/70;C07C45/74;C07C51/363;C07C253/30;C07C319/14;C07C323/03;C07C323/09;(IPC1-7):C07B39/00;C07C33/46 |
主分类号 |
C07C29/38 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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