| 摘要 |
2-Aminocyclopentane(carboxylic or phosphonic) acid derivatives of formula (I) are new. R1, R2 = H, halo, 3-6C cycloalkyl, or 1-8C alkyl (optionally mono- or disubstituted by halo, OH, Ph, COOH or n-alkoxy or alkoxycarbonyl; R3, R4 = halo, or 1-8C alkyl or cycloalkyl with up to 8C (both optionally mono- or disubstituted by halo, OH, Ph, COOH, alkoxy, acyl or alkoxycarbonyl); R5 = H, 1-8C alkyl (optionally mono- or disubstituted by OH, CHO, acyl, Ar or COAr), 1-8C acyl, COAr or SO2R8; Ar = phenyl (optionally mono- or disubstituted by halo, NO2, CN or alkyl); R6 = H or 1-8C alkyl (optionally substituted by Ph); or R5+ R6 =CHR8; R7 = COAR9 or P(X)(X'R10)2; A = O, S or NH; X, X<1> = O or S; R8 = 1-8C alkyl, COAr' or Ar'; Ar' = phenyl (optionally mono-, di- or trisubstituted by halo, OH, NO2, CN, CF3, OCF3, COOH, alkyl, alkoxy or alkoxycarbonyl); R9 = H, 1-8C alkyl (optionally mono-, di- or trisubstituted by OH, halo, NO2, CN, COOH, CF3, OCF3, alkoxy or SO2R8) or Ph (optionally mono-, di- or trisubstituted by OH, halo, NO2, CN, COOH, CF3, OCF3, alkoxy, alkyl, acyl, alkoxycarbonyl or SO2R8); and when A = NH, then R9 = SO2R8; R10 = H, 1-8C alkyl (optionally mono-, di- or trisubstituted by OH, halo, NO2, CN, COOH, CF3, OCF3 or alkoxy) or Ph (optionally mono-, di- or trisubstituted by OH, halo, NO2, CN, COOH, CF3, OCF3, alkoxy, alkyl, acyl or alkoxycarbonyl) or cycloalkyl with up to 8C (optionally mono- or disubstituted by halo, OH, Ph, COOH or alkyl, acyl or alkoxycarbonyl). alkoxy, alkyl, acyl, alkoxycarbonyl have up to 6C unless specified otherwise.
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