发明名称 |
Preparation of agarose coated, solid agarose-collagen beads containing secretory cells |
摘要 |
Biological agents such as secretory cells are encapsulated in a hydrophilic gel made of agarose or collagen-agarose and gelatin sponge-agarose combinations. In a preferred embodiment, semi-solid beads are formed from a suspension containing collagen, agarose and secretory cells such as pancreatic islets, the collagen is polymerized to form solid, agarose-collagen beads and the solid beads are coated with agarose. Coating is preferably by rolling the solid beads in about 5-10% agarose, contacting the rolled beads with mineral oil and washing oil from the beads. Beads containing secretory cells can be transplanted into a mammal to treat a condition caused by impaired secretory cell function.
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申请公布号 |
US5643569(A) |
申请公布日期 |
1997.07.01 |
申请号 |
US19950483728 |
申请日期 |
1995.06.07 |
申请人 |
THE ROGOSIN INSTITUTE |
发明人 |
JAIN, KANTI;RUBIN, ALBERT L.;SMITH, BARRY H. |
分类号 |
A61K9/16;A61K9/50;A61K35/12;A61K35/28;A61K35/39;A61K38/00;A61K47/26;A61K47/36;A61P3/10;C12N5/00;C12N5/07;C12N5/071;C12N11/04;C12N11/10;(IPC1-7):A61K35/12;C12N11/02 |
主分类号 |
A61K9/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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