发明名称 |
Hemostatic patch |
摘要 |
A fibrogen-free substrate having as a hemostatic agent on a surface thereof a mixture of a clot-promoting amount of thrombin and an amount of epsilon aminocaproic acid (EACA) effective to accelerate the rate of blood clotting induced by the thrombin is useful as a hemostatic patch which is safe, inexpensive and which rapidly controls bleeding from a wound. A patch which rapidly stanches the flow of blood from a lesion on a parenchymal organ by pressing it against the surface of the organ for 3-5 minutes, is produced by applying thrombin, EACA and CaCl2 to a rigid sheet of biodegradable foam, such as an absorbable gelatin sponge, and compressing the dry sheet to produce a flexible sheet which conforms to the contour of the organ without the necessity of pre-moistening. The problem associated with thrombin-fibrinogen glues of adhesion of the wounded surface of the organ to adjacent tissue is avoided by applying the hemostatic agent to only the wound-contacting face of the sheet.
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申请公布号 |
US5643596(A) |
申请公布日期 |
1997.07.01 |
申请号 |
US19950474127 |
申请日期 |
1995.06.07 |
申请人 |
CLARION PHARMACEUTICALS, INC. |
发明人 |
PRUSS, THADDEUS P.;WILL, JAMES A. |
分类号 |
A61F13/00;A61F13/02;A61L15/44;A61L15/58;A61L15/64;A61L24/00;A61L26/00;(IPC1-7):A61K9/70 |
主分类号 |
A61F13/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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