摘要 |
FIELD: chemistry of peptides. SUBSTANCE: invention proposes peptide of the following formula: $$$ where: $$$ - amino acid or peptide containing one or at least two basic amino acids taken from lysine, arginine and ornithine being in this amino acids or peptide amino-end N-$$$ can be substituted with acyl group or substituted thiocarbamoyl group; $$$ means tyrosine or arginine; $$$ means lysine or arginine; $$$ means -OH or $$$; X means peptide: D-ornithyl-proline, prolyl-D-ornithine, D-lysyl-proline, prolyl-D-lysine, D-arginyl-proline, prolyl-D-arginine, glycyl-ornithine, ornithyl-glycine, glycyl-lysine, lysyl-glycine, glycyl-arginine and arginyl-glycine where hydrogen atom of $$$-amino-group of D-lysine, L-lysine, D-ornithine and L-ornithine can be substituted with $$$-amino-group. This peptide is linked with amino acid residues at positions 6 and 8 by peptide bond per se. Example of this peptide is presented by the following formula (I) $$$. Polypeptide can be used in pharmaceutical composition as antimicrobial and antiviral agent, in part, for HIV control and as component of DNA-transfecting system for genetic therapy. EFFECT: new polypeptide. |