NUCLEOTIDE SEQUENCES, PROTEINS, DRUGS AND DIAGNOSTIC AGENTS FOR TREATING CANCER

摘要

A nucleotide sequence corresponding to a gene comprising (a) one of sequences SEQ ID 1 to 11, or an equivalent gene which comprises (b) a sequence hybridisable with one of the sequences of (a), (c) a sequence at least 80 % homologous with (a) or (b), or (d) a sequence coding for a protein encoded by a gene according to (a), (b) or (c), or for an equivalent protein, and the use thereof, in particular for controlling cancer as well as for therapeutic follow-up. These genes are in the TSAP (tumor suppressor activated pathway) group, designated TSAP 1 to TSAP 8 and TSAP 3 human (or HUMSIAH) and in TSIP (tumor suppressor inhibited pathway) group, designated TSIP 1 and TSIP 2, both types of genes corresponding to sequences activated or inhibited, respectively, during cellular apoptosis, particularly that induced by p53.