| 摘要 |
3,3a,4,5-Tetrahydro-1H-oxazolo[3,4-a]quinolin-1-one derivatives of formula (I) <IMAGE> (I) in which: n is 0 or 1, R1 represents a hydrogen atom or an ethenyl, methyl, ethyl, phenyl, hydroxymethyl or methoxymethyl group, and (i) R2 is a methyl, trifluoromethyl or cyano group, R3 is a hydrogen atom or a hydroxyl or benzyloxy group and R4 and R5 are hydrogen atoms, or (ii) R2 and R4 together form a -(CH2)4- group, R3 is a hydroxyl group and R5 is a hydrogen atom, or (iii) R2 and R5 together form an -O-(CH2)3- group, and R3 and R4 are hydrogen atoms, or (iv) R2 and R5 together form a -(CH2)4 group, R3 is a hydroxyl group and R4 is a hydrogen atom, are useful as selective inhibitors of MAO-A or as mixed inhibitors of MAO-A and MAO-B.
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