| 摘要 |
The present invention is a method of treating non-insulin-dependent diabetes mellitus comprising administering to a patient in need thereof a therapeutically effective amount of at least one compound of general formula (I) for a period of time of more than 6 days, wherein Y is O; R is OH, NHCONR<4>R<5>, or N=C(NR<4>R<5>)2; R<4> and R<5> are each independently selected from the group consisting of hydrogen; C1-10 alkyl, straight or branched chain; aryl C1-4 alkyl; and mono- or disubstituted aryl C1-4 alkyl where the substituents are fluoro, chloro, bromo, iodo or C1-10 alkyl, straight or branched chain; R<1> and R<2> are each independently selected from the group consisting of hydrogen, amino, and mono- or di-substituted chain C3-8, cycloalkyl; provided that R<1> and R<2> may not both be amino or substituted amino; and R<3> is hydrogen, trifluoromethyl, fluoro, chloro, bromo, or iodo; or a pharmaceutically acceptable salt thereof.
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