METHODS AND COMPOSITIONS FOR MODULATING VESICLE RELEASE

摘要

This invention provides methods and compositions useful for modulating synaptic transmission. The compositions of this invention are complexes comprised of various combinations of proteins, such as tagmin, beta -SNAP, NSF, alpha -SNAP, and SNAREs involved in docking and fusion of synaptic vesicles to membranes. In addition, this invention relates to complexes of tagmin and special phospholipids (phosphatidyl inositols) which are a component of membranes involved in the secretory process. These complexes are useful for identifying other substances which may modulate synaptic transmission.