| 摘要 |
PROBLEM TO BE SOLVED: To obtain tetrahydrobiopterin hydrochloride useful for medicines, etc., in a high asymmetric synthesis degree in a high purity and in a high yield by catalytically reducing erythrobiopterin, etc., in the presence of an amine compound and platinum black as a catalyst in a prescribed alkaline pH region. SOLUTION: L-Erythrobiopterin or its acyl derivative represented by formula I (R is H, an acyl) is catalytically reduced in the presence of an amine compound and platinum black as a catalyst in water and/or an alcoholic solvent at a pH of 10-13 at a temperature of <=20 deg.C under a hydrogen gas pressure of >=20 kg/cm<2> . When the product has the acyl group, the acyl group is further removed. Thus, (6R)-tetrahydro-L-biopterin hydrochloride of formula II is obtained. |
