| 摘要 |
PCT No. PCT/GB96/02853 Sec. 371 Date May 18, 1998 Sec. 102(e) Date May 18, 1998 PCT Filed Nov. 20, 1996 PCT Pub. No. WO97/19084 PCT Pub. Date May 29, 1997The present invention relates to compounds of formula (I), wherein R1 represents halogen, hydroxy, C1-6alkyl group optionally substituted by one or three fluorine atoms, C1-6alkoxy group optionally substituted by one to three fluorine atoms, or C1-6alkylthio optionally substituted by one to three fluorine atoms; R2 represents hydrogen, halogen, C1-6alkyl or C1-6alkoxy; or when R2 is adjacent to R1, they may be joined together such that there is formed a 5- or 6-membered saturated or unsaturated ring containing one or two oxygen atoms; R3 represents an optionally substituted 5- or 6-membered aromatic heterocyclic group containing 1, 2, 3 or 4 heteroatoms, selected from nitrogen, oxygen and sulphur; m is 0-3 and n is 0-3, with the proviso that the sum total of m+n is 2 or 3; p is zero or 1; q is 1 or 2; and when m is 1 and n is 1 or 2, the broken line represents an optional double bond; R4, R5, R6, R9 and R10 are a variety of substituents defined in the specification; or a pharmaceutically acceptable salt thereof. The compounds are of particular use in the treatment or prevention of pain, inflammation, emesis and postherpetic neuralgia. |
