METHOD FOR PRODUCTION OF TAXANE DERIVATIVES AND β-LACTAM INTERMEDIATE COMPOUNDS FOR THEY

摘要

FIELD: organic synthesis, medicine. SUBSTANCE: taxane derivatives and analogies thereof are prepared by using of b-lactam intermediates, the process is followed by their combination with baccatine-III. Compounds have high cytotoxic and high antitumor activity. EFFECT: improved antitumor activity.