摘要 |
The chiral derivatives of hydroxyphenylglycin, with the configuration D, have general formula (I), wherein R is H, hydroxy, chloride, -NH2, -NHW, wherein W is an alkyl C1-C4 or aryl group, -OR', wherein R' is an alkyl C1-C4 group, and Z is H, -CONH2 and -C(CH3)=CHCOOY, wherein Y is methyl or ethyl. One of said compounds, D-(-)-2-(2'-hydroxyphenyl)glycin, may be obtained by enzymatic process from the corresponding hydantoin while the others may be obtained by chemical or enzymatic process. The compounds of formula (I) are useful for the production of drugs, particularly for semisynthetic penicillins, cephalosporins, non steroid and mucolytic antiinflammatory agents. |
申请人 |
DERIVADOS DEL ETILO, S.A.;ESTEBAN MORALES, MANUEL;PALLARES BAYO, ANTONIO |
发明人 |
ESTEBAN MORALES, MANUEL;PALLARES BAYO, ANTONIO |