| 摘要 |
PCT No. PCT/GB94/00307 Sec. 371 Date Aug. 25, 1995 Sec. 102(e) Date Aug. 25, 1995 PCT Filed Feb. 26, 1994 PCT Pub. No. WO94/19338 PCT Pub. Date Sep. 1, 1994Described herein is a process for the preparation of (1S,2R)-1,2-epoxy-1,2,3,4-tetrahydronaphthalene having the Formula (I): <IMAGE> Formula (I) which comprises the steps of (a) hydrogenating the compound of Formula (II) to form cis-(1R, 2S)-1,2-dihydroxy-1,2,3,4-tetrahydronaphthalene having the Formula (V): <IMAGE> (b) reacting the dihydroxy compound of Formula (V) with a sulphonyl halide of formula R1SO2Z wherein R1 is methyl, ethyl, trifluoromethyl, phenyl or p-tolyl, and Z is fluorine, chlorine, bromine or iodine to give a bis-sulphonyl ester of formula (X): <IMAGE> and (c) treating the bis-sulphonyl ester (X) with an alkali metal carbonate or alkali metal hydroxide to give the compound of Formula (I). |
