SESQUITERPENE DERIVATIVE, ITS PRODUCTION AND ICAM-1 EXPRESSION-INHIBITING AGENT CONTAINING THE SAMES AS ACTIVE INGREDIENT

摘要

PROBLEM TO BE SOLVED: To obtain a new sesquiterpene derivative useful as an active ingredient for expression-inhibiting medicines against ICAM-1 especially playing an important role on the adhesion of leukocytes to vascular endothelial cells as a cell- adhesive factor, and finally used as a new antiallergic medicine. SOLUTION: This sesquiterpene of formula I (R is a group of formula II or III). The sesquiterpene of formula I is obtained by culturing Pithomyces chartarum, an imperfect fungus belonging to the genus Pithomyces and having an ability to produce the sesquiterpene derivative, and subsequently separating and purifying the culture product with various kinds of column chromatography.