发明名称 |
Carboxyalkyl substituted inhibitors of enkephalinase and ACE |
摘要 |
<p>The present invention relates to compounds of the formula <CHEM> wherein B<5> and B<6> are each independently hydrogen; hydroxy; -OR<6> wherein R<6> is a C<5>-C<8> alkyl or an Ar-Y group wherein Ar is aryl and Y is a hydrogen or C<5>-C<8> alkyl; or, where B<5> and B<6> are attached to adjacent carbon atoms, B<5> and B<6> can be taken together with said adjacent carbons to form a benzene ring or methylenedioxy; A is a bond, methylene or oxygen, sulfur or NR<8> or NCOR psi wherein R<8> is hydrogen, a C<5>-C<8> alkyl or an Ar-Y- group and R psi is -CF<7>, a C<5>-C<5><4> alkyl or an Ar-Y- group; R<7> is hydrogen or -CH<6>OC(O)C(CH<7>)<7>; R<5> is hydrogen, C<5>-C<8> alkyl or -CH<6>OC(O)-C(CH<7>)<7>; and n is an integer 1 to 3, which are useful as inhibitors of enkephalinase and ACE.</p> |
申请公布号 |
GR3022654(T3) |
申请公布日期 |
1997.05.31 |
申请号 |
GR19970400341T |
申请日期 |
1997.02.26 |
申请人 |
MERRELL PHARMACEUTICALS INC. |
发明人 |
WARSHAWSKY, ALAN M.;FLYNN, GARY A. |
分类号 |
A61K31/535;A61K31/54;A61K31/55;A61K38/00;A61P7/10;A61P9/00;A61P9/12;A61P25/04;A61P25/28;A61P43/00;C07D471/04;C07D487/04;C07D498/04;C07D507/00;C07D513/04;C07K5/078;(IPC1-7):C07K5/078;A61K38/05 |
主分类号 |
A61K31/535 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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