PRODUCTION OF OPTICALLY ACTIVE 2-SUBSTITUTED TETRAHYDROPYRAN-4-ONES
摘要
Optically active 2-substituted tetrahydropyran-4-ols or esters thereof may be prepared using esterases or hydrolases from the corresponding racemic mixtures of esters or alcohols. This provides a route to the corresponding optically active ketones. The racemic mixtures are preferably in the cis-form. Such mixtures may be produced by reacting but-3-ene-1-ol with an aldehyde in the presence of an acid.
申请公布号
WO9719185(A1)
申请公布日期
1997.05.29
申请号
WO1996GB02838
申请日期
1996.11.19
申请人
ZENECA LIMITED;HOLT, ROBERT, ANTONY;RIGBY, STUART, RICHARD;WATERSON, DAVID
发明人
HOLT, ROBERT, ANTONY;RIGBY, STUART, RICHARD;WATERSON, DAVID