发明名称 INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE
摘要 The present invention is directed to compounds which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting farnesyl-protein transferase and the farnesylation of the oncogene protein Ras.
申请公布号 WO9718813(A1) 申请公布日期 1997.05.29
申请号 WO1996US18811 申请日期 1996.11.18
申请人 MERCK & CO., INC.;KIM, BYEONG, M.;SHAW, ANTHONY, W.;GRAHAM, SAMUEL, L.;DESOLMS, S., JANE;CICCARONE, TERRENCE, M. 发明人 KIM, BYEONG, M.;SHAW, ANTHONY, W.;GRAHAM, SAMUEL, L.;DESOLMS, S., JANE;CICCARONE, TERRENCE, M.
分类号 A61K31/00;A61K31/4427;A61K31/445;A61K31/4465;A61K31/4523;A61K31/454;A61K31/535;A61K31/5375;A61K31/5377;A61P9/00;A61P13/00;A61P13/12;A61P27/00;A61P27/02;A61P31/00;A61P31/12;A61P35/00;A61P43/00;C07D233/24;C07D401/12;(IPC1-7):A61K31/445 主分类号 A61K31/00
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