发明名称 USE OF NAPHTHOQUINONE COMPOUNDS AS ANTIPROTOZOAL AGENTS
摘要 <p>The use of a compound of general formula (I) or a salt thereof as a medicament is provided, in which n represents an integer from 0 to 4; m represents an integer 0 or 1; each R independently represents a halogen atom or a nitro, cyano, hydroxyl, alkyl, alkenyl, haloalkyl, haloalkenyl, alkoxy, haloalkoxy, haloalkenoxy, amino, alkylamino, dialkylamino, alkoxycarbonyl, carboxyl, alkanoyl, alkylthio, alkylsulphinyl, alkylsulphonyl, carbamoyl, alkylamido, cycloalkyl, aryl or aralkyl group; R?1 and R2¿ each independently represent an optionally substituted alkoxy group or together represent a group =O, =S or =N-OR9, where R9 represents a hydrogen atom or an optionally substituted alkyl group; R3 represents a hydroxyl group, or a group-OL where L is a leaving group, or a group which in vivo is transformed into a group -OL1 where L1 is a leaving group; R6 represents an optionally substituted alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, aryl, alkoxy, alkenyloxy, alkynyloxy, cycloalkyloxy, cycloalkenyloxy or aryloxy group; R?7 and R8¿ independently represent an optionally substituted alkoxy group or together represent a group =O, =S or =N-OR9, where R9 is as previously defined; wherein R¿4? and R5 independently represent a halogen atom or an optionally substituted alkyl or alkenyl group, or together with the interjacent carbon atom represent an optionally substituted cycloalkyl or cycloalkenyl group; and A represents a straight or branched chain alkyl or alkenyl group, which may be optionally substituted, preferably with halogen, an acyclic carbon chain of which links the 3 position of the naphthalene ring shown and the moiety -CR?4R5R6¿.</p>
申请公布号 WO1997018800(A1) 申请公布日期 1997.05.29
申请号 GB1996002872 申请日期 1996.11.21
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