发明名称 |
SUBSTITUTED 1-INDOLYLPROPYL-4-BENZYL-TETRAHYDROPYRIDINE DERIVATIVES |
摘要 |
A class of 1-[3-(1H-indol-3-yl)propyl]-4-benzyl-1,2,5,6-tetrahydropyridine derivatives, substituted at the 5-position of the indole nucleus by a 1,2,4-triazol-4-yl moiety, and on the methylene linkage of the benzyl moiety by an alkyl, alkoxy or alkoxy-alkoxy substituent, are selective agonists of 5-HT1-like receptors, being potent agonists of the human 5-HT1D alpha receptor subtype whilst possessing at least a 10-fold selective affinity for the 5-HT1D alpha receptor subtype relative to the 5-HT1D beta subtype; they are therefore useful in the treatment and/or prevention of clinical conditions, in particular migraine and associated disorders, for which a subtype-selective agonist of 5-HT1D receptors is indicated, whilst eliciting fewer side-effects, notably adverse cardiovascular events, than those associated with non-subtype-selective 5-HT1D receptor agonists.
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申请公布号 |
WO9717337(A1) |
申请公布日期 |
1997.05.15 |
申请号 |
WO1996GB02684 |
申请日期 |
1996.11.04 |
申请人 |
MERCK SHARP & DOHME LIMITED;BOURRAIN, SYLVIE;MACLEOD, ANGUS, MURRAY;NEDUVELIL, JOSEPH, GEORGE;SHOWELL, GRAHAM, ANDREW |
发明人 |
BOURRAIN, SYLVIE;MACLEOD, ANGUS, MURRAY;NEDUVELIL, JOSEPH, GEORGE;SHOWELL, GRAHAM, ANDREW |
分类号 |
C07D521/00;(IPC1-7):C07D401/14;A61K31/44 |
主分类号 |
C07D521/00 |
代理机构 |
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