ADENOVIRUS-MEDIATED PRODUCTION OF BIOACTIVE PROTEINS BY MAMMALIAN CELLS AND ANIMALS

摘要

The invention provides a method for producing bioactive compounds useful for therapeutic therapy in humans and non-human animals. Said compounds are produced by an adenoviral vector containing a DNA encoding an amino acid sequence for a protein. The DNA sequence is operative linked to a promoter and is injected into culture mammalian cells or into animals. Said vector produces a protein which is then post-translationally modified by the cultured mammalian cells or the animal to produce a bioactive compound. The bioactive compound is isolated from the cultured cells, or animal fluid, cells or organs.