Method for treating fermentation broth

摘要

The present invention relates to a method of improving a membrane permeation rate when permeating a fermentation broth obtained by culturing a microorganism belonging to the genus Escherichia through a membrane to separate cells is developed. More specifically it relates to a method of treating a fermentation broth, characterized in that a fermentation broth obtained by culturing a microorgasm belonging to the genus Escherichia is heat-treated at from 110 to 200 DEG C with a pH of from 1 to 4.5, and is then filtered through the membrane. The membrane permeation rate of the fermentation broth in the removal of cells therefrom can be improved by from approximately 1.5 to 20 times in comparison to the case where the treatment of the present invention is not conducted. Therefore, the membrane permeation rate can easily be improved and the efficiency of the membrane filtration equipment can be increased.