发明名称 |
METHODS OF TREATING ESTABLISHED COLITIS USING ANTIBODIES AGAINST IL-12 |
摘要 |
The present invention provides a method for treating the inflammatory response of an established colitis in a subject with inflammatory bowel disease (IBD) comprising administering to a subject diagnosed with an established colitis from an IBD an amount of an antibody to interleukin-12 effective in reducing the colitis-inducing effect of interleukin-12. Also provided is a method for screening a substance for its effectiveness in reducing the inflammatory response of an established colitis. Additionally, the present invention provides a method for screening a substance for its effectiveness in preventing inflammatory bowel disease.
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申请公布号 |
CA2235866(A1) |
申请公布日期 |
1997.05.01 |
申请号 |
CA19962235866 |
申请日期 |
1996.03.29 |
申请人 |
THE GOVERNMENT OF THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRE TARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES |
发明人 |
NEURATH, MARKUS;FUSS, IVAN;STROBER, WARREN |
分类号 |
G01N33/53;A61K31/00;A61K38/00;A61K39/395;A61P1/00;C07K16/24;C12N15/09;C12N15/24;C12P21/08;G01N33/15;(IPC1-7):A61K39/395;C12Q1/00;G01N33/48 |
主分类号 |
G01N33/53 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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