PEPTIDE INHIBITORS OF A PHOSPHOTYROSINE-BINDING DOMAIN CONTAINING PROTEIN

摘要

A peptide of the formula (I): X?1-A1-A2-X2-Asn-X3-X4¿-P.Tyr-X?5-X6-X7-X8¿, wherein X1 represents Lys, Arg, His, Ser, Thr, Tyr, Asn, Leu, Val or Glu, A1 represents Trp, Leu, Ala, Ser, Ile, Glu, Met, Gly, Cys, Phe, Pro or Val, and A2 represents Ala, Val, Leu, Ile, Ser, Met, Phe, Gly, Cys, Trp or Pro, X2 represents Glu, Asn, Tyr, Thr, Ser, Asp or Ile, X3 represents Pro, Met, Trp, Phe, Ala, Lys, Val, Leu, Ile, Gly or Cys, X4 represents Leu, Ala, Glu, Gln, Asp, Asn, Tyr, Thr or Ser, X5 represents Phe, Trp, Pro, Leu, Ala, Val, Ile, Gly, Cys, Met, Arg or Ser, X6 represents Ser, Thr, Tyr, Asn, Glu, Met, Ala, Leu, Val or Gly, X7 represents Asp, Glu, Ala, Val, Leu, Ile, Gly, Cys, Phe, Trp, Met, Pro, Ser or Asn and X8 which may be present or absent represents Phe, Trp, Pro, Leu, Ala, Val, Ile, Gly, Cys, Met, Asp, Ser or Arg which interferes with the interaction of a PTB domain containing protein with a PTB domain binding site, and truncations and analogues of the peptide.